Publications by core members relating to targeting and transgenic technologies
- LePage DF, Church DM, Millie E, Hassold TJ, Conlon RA. (2000) Rapid generation of nested chromosomal deletions on mouse chromosome 2. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10471-6.
- A technique for generation of large, multigenic deletions utilizing gene targeting and site-specific recombinases is described.
- Scott MM, Wylie CJ, Lerch JK, Murphy R, Lobur K, Herlitze S, Jiang W, Conlon RA, Strowbridge BW, Deneris ES. (2005) A genetic approach to access serotonin neurons for in vivo and in vitro studies. Proc Natl Acad Sci U S A. 102(45):16472-7.
- Large genomic clones in BAC vectors are used to generate transgenic mice specifically expressing makers and recombinases in serotonergic neurons of the central nervous system.
- LePage DF, Conlon RA. (2006) Animal models for disease: knockout, knock-in, and conditional mutant mice. Methods Mol Med. 2006;129:41-67.
- The practical aspects of gene targeting are described in this methods paper.
- Conlon RA. (2011) Transgenic and Gene Targeted Models of Dementia, In: Animal models of Dementia. Neuromethods (Springer) 48:77.
- Gene targeting and transgenics are compared for their ability to generate robust models of dementia.